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Nontyphoidal Salmonella are a major and emerging cause of fatal invasive disease in Africa, and are genetically distinct from those found elsewhere in the world. Understanding the targets of protective immunity to these African Salmonellae is key to vaccine development. We immunized mice and rabbits with heat-inactivated wild-type African invasive Salmonella Typhimurium D23580 and rough mutants lacking O-antigen. Wild-type Salmonella, unlike rough bacteria, induced a large bactericidal antibody response mainly against O-antigen. Bactericidal ability of anti-O-antigen antibodies was confirmed following purification by affinity chromatography. The current findings support the development of an O-antigen conjugate vaccine against invasive nontyphoidal Salmonellae for Africa.

Original publication

DOI

10.1016/j.micpath.2013.05.014

Type

Journal article

Journal

Microb Pathog

Publication Date

10/2013

Volume

63

Pages

19 - 23

Keywords

Conjugate vaccine, NTS, Nontyphoidal Salmonella, O-antigen, Animals, Antibodies, Bacterial, Blood Bactericidal Activity, Humans, Mice, O Antigens, Rabbits, Salmonella Infections, Salmonella Vaccines, Salmonella typhimurium, Vaccination