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We have produced a novel, simple and rapid method utilising genetically encodable FRET-based biosensors to permit the detection of HIV-1 virion fusion in living cells. These biosensors show high sensitivity both spatially and temporally, and allow the real-time recovery of HIV-1 fusion kinetics in both single cells and cell populations simultaneously.

Original publication

DOI

10.1038/srep13449

Type

Journal article

Journal

Sci Rep

Publication Date

24/08/2015

Volume

5

Keywords

Biosensing Techniques, Computer Systems, Fluorescence Resonance Energy Transfer, HEK293 Cells, HIV-1, Humans, Imaging, Three-Dimensional, Virion, Virus Internalization