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The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.

Type

Journal article

Journal

Trends Immunol

Publication Date

02/2001

Volume

22

Pages

83 - 87

Keywords

Amino Acid Sequence, Animals, Chemokine CCL5, Chemokines, Humans, Inflammation, Models, Molecular, Molecular Sequence Data