Optimal Cutoff Titers for Indirect Immunofluorescence Assay for Diagnosis of Scrub Typhus
Lim C., Blacksell SD., Laongnualpanich A., Kantipong P., Day NPJ., Paris DH., Limmathurotsakul D.
ABSTRACT We determined the optimal cutoff titers in admission and convalescent-phase samples for scrub typhus indirect immunofluorescence assay using Bayesian latent class models. Cutoff titers of ≥1:3,200 in an admission sample or of a ≥4-fold rise to ≥1:3,200 in a convalescent-phase sample provided the highest accuracy (sensitivity, 81.6%; specificity, 100%).