Gene Amplification of the Multidrug Resistance 1 Gene of Plasmodium vivax Isolates from Thailand, Laos, and Myanmar
Imwong M., Pukrittayakamee S., Pongtavornpinyo W., Nakeesathit S., Nair S., Newton P., Nosten F., Anderson TJC., Dondorp A., Day NPJ., White NJ.
ABSTRACT Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1 , independent of gene amplification, were also found.