Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
Fedorov O., Castex J., Tallant C., Owen DR., Martin S., Aldeghi M., Monteiro O., Filippakopoulos P., Picaud S., Trzupek JD., Gerstenberger BS., Bountra C., Willmann D., Wells C., Philpott M., Rogers C., Biggin PC., Brennan PE., Bunnage ME., Schüle R., Günther T., Knapp S., Müller S.
PFI-3, a novel inhibitor targeting the bromodomains of essential components of the BAF/PBAF complex, affects the differentiation of ESC and TSC.