Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course.

Original publication

DOI

10.1128/JVI.00116-10

Type

Journal article

Journal

J Virol

Publication Date

08/2010

Volume

84

Pages

8202 - 8208

Keywords

Adult, Africa, Western, Aged, Disease Progression, Ethnic Groups, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, HIV Infections, HIV-2, HLA-B Antigens, HLA-B8 Antigen, Histocompatibility Antigens Class I, Humans, Male, Middle Aged, Polymorphism, Genetic, Receptors, KIR