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We report a 66% reduction in neonatal tetanus mortality after introducing a new management bundle integrating antibiotic therapy, muscle relaxation and invasive monitoring. The latter allowed rapid detection of autonomic instability which was treated with magnesium sulphate. This is the first report of its use in neonatal tetanus.

Original publication

DOI

10.1093/jpids/piv059

Type

Journal article

Journal

J Pediatric Infect Dis Soc

Publication Date

06/2016

Volume

5

Pages

227 - 230

Keywords

autonomic dysfunction, magnesium sulfate, neonatal tetanus, Anti-Bacterial Agents, Blood Pressure Determination, Critical Care, Humans, Hypnotics and Sedatives, Infant, Newborn, Magnesium Sulfate, Monitoring, Physiologic, Neuromuscular Agents, Positive-Pressure Respiration, Retrospective Studies, Tetanus, Vietnam