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The endosomal compartment, which contains all the components required for loading peptides onto MHC class II molecules, is classically considered to be dedicated to the loading of MHC class II but not MHC class I molecules. However, a report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2014. 44: 774-784], together with other recent studies, shows that the endosomal compartment also supports efficient loading of MHC class I molecules. These results bring a new perspective on the crosstalk between the MHC class II and MHC class I antigen-processing pathways, and may inspire new ideas for the design of vaccines against viruses and tumors.

Original publication




Journal article


Eur J Immunol

Publication Date





650 - 653


Antigen presentation/processing, CD8+ T cells, MHC, Vaccination, Antigen Presentation, Antigens, Antigens, Differentiation, B-Lymphocyte, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Humans, Lymphocyte Activation, Peptides, T-Lymphocytes, Cytotoxic