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T cell defined antigens have now been characterized in a large variety of tumor types, in both mice and humans. An increasing number of these antigens appear to result from tumor-specific mutations, and some of these mutations may be implicated in oncogenesis. The priority is now to demonstrate that immunization against some of these antigens is clinically valuable for antitumor therapy, and the first results of clinical pilot studies are now emerging.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

10/1997

Volume

9

Pages

684 - 693

Keywords

Animals, Antigen Presentation, Antigens, Neoplasm, Cytotoxicity, Immunologic, Humans, Mice, Mutation, T-Lymphocytes