Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.

Type

Journal article

Journal

Immunogenetics

Publication Date

1996

Volume

44

Pages

323 - 330

Keywords

Amino Acid Sequence, Animals, Antigen Presentation, Antigens, Neoplasm, Base Sequence, Carcinoma, Renal Cell, Cell Line, Transformed, Cercopithecus aethiops, DNA, Complementary, Eye Proteins, Genes, HLA-B7 Antigen, Humans, Kidney Neoplasms, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Neoplasms, Retina, Sequence Alignment, Sequence Homology, T-Lymphocytes, Cytotoxic, Transfection