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Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.


Journal article



Publication Date





323 - 330


Amino Acid Sequence, Animals, Antigen Presentation, Antigens, Neoplasm, Base Sequence, Carcinoma, Renal Cell, Cell Line, Transformed, Cercopithecus aethiops, DNA, Complementary, Eye Proteins, Genes, HLA-B7 Antigen, Humans, Kidney Neoplasms, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Neoplasms, Retina, Sequence Alignment, Sequence Homology, T-Lymphocytes, Cytotoxic, Transfection