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Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.

Original publication

DOI

10.1038/ng.585

Type

Journal article

Journal

Nat Genet

Publication Date

06/2010

Volume

42

Pages

492 - 494

Keywords

Case-Control Studies, Chromosomes, Human, Pair 9, Genes, p16, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma