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Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum.

Original publication

DOI

10.1086/653211

Type

Journal article

Journal

J Infect Dis

Publication Date

01/07/2010

Volume

202

Pages

109 - 112

Keywords

Animals, E-Selectin, Gene Expression Regulation, Humans, Indonesia, Inflammation, Intercellular Adhesion Molecule-1, Interleukin-10, Interleukin-6, Malaria, Falciparum, Malaria, Vivax, Plasmodium falciparum, Plasmodium vivax, Weibel-Palade Bodies