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Vertical transmission of Plasmodium falciparum is under-recognized and usually associated with asymptomatic low-level parasitemia at birth. We report symptomatic congenital malaria presenting as a neonatal sepsis syndrome. The presence at birth of a high asexual parasitemia, gametocytemia, and splenomegaly indicated in utero rather than intrapartum transmission. The neonate was successfully treated with intravenous artesunate followed by oral dihydroartemisinin-piperaquine, without apparent adverse effects.

Original publication

DOI

10.4269/ajtmh.2010.09-0744

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

04/2010

Volume

82

Pages

563 - 565

Keywords

Adult, Antimalarials, Artemisinins, Artesunate, Female, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Malaria, Falciparum, Pregnancy, Quinolines