Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

AbstractVaccines to protect against tuberculosis (TB) are urgently needed. We performed a case–control analysis to identify immune correlates of TB disease risk in Bacille Calmette–Guerin (BCG) immunized infants from the MVA85A efficacy trial. Among 53 TB case infants and 205 matched controls, the frequency of activated HLA-DR+CD4+T cells associates with increased TB disease risk (OR=1.828, 95% CI=1.25–2.68,P=0.002, FDR=0.04, conditional logistic regression). In an independent study ofMycobacterium tuberculosis-infected adolescents, activated HLA-DR+CD4+T cells also associate with increased TB disease risk (OR=1.387, 95% CI=1.068–1.801,P=0.014, conditional logistic regression). In infants, BCG-specific T cells secreting IFN-γ associate with reduced risk of TB (OR=0.502, 95% CI=0.29–0.86,P=0.013, FDR=0.14). The causes and impact of T-cell activation on disease risk should be considered when designing and testing TB vaccine candidates for these populations.

Original publication




Journal article


Nature Communications


Springer Science and Business Media LLC

Publication Date