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Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs.

Original publication

DOI

10.1080/2162402X.2015.1072675

Type

Journal article

Journal

Oncoimmunology

Publication Date

03/2016

Volume

5

Keywords

DNA polymerase ε, POLE, neopeptide, ultramutation