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In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 status.

Original publication

DOI

10.1016/j.ccell.2016.04.010

Type

Journal article

Journal

Cancer Cell

Volume

29

Pages

619 - 621

Keywords

Humans, Melanoma, Mitochondria, Mutation, Proto-Oncogene Proteins B-raf, RNA, Long Noncoding