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U.K. guidelines for vaccinating HIV-infected adults against bacteria are based on limited data. We compared antibody responses between 211 HIV-infected and 73 HIV-uninfected adults vaccinated with pneumococcal polysaccharide vaccine (PPV) and Haemophilus influenzae b/meningococcal C polysaccharide-tetanus toxoid glycoconjugate vaccine (Hib/MenC-TT). IgG responses to Hib/MenC-TT were not significantly different. PPV induced median IgGs >1.3 μg/mL for 10/12 serotypes among HIV-uninfected participants and 5/12 in HIV-infected participants. HIV-uninfected adults had higher post-vaccination IgGs than HIV-infected adults for 4/12 serotypes (P < 0.001). Responses did not associate with CD4 count or viral suppression. In a U.K. HIV-infected population, Hib/MenC-TT induced similar responses to HIV-uninfected adults, whereas PPV induced poor responses.

Original publication




Journal article


J Acquir Immune Defic Syndr

Publication Date





287 - 293


AIDS-Related Opportunistic Infections, Adult, Antibodies, Bacterial, Bacterial Capsules, Female, HIV Infections, Haemophilus Vaccines, Humans, Immunization, Immunization Schedule, Male, Meningococcal Vaccines, Pneumococcal Infections, Pneumococcal Vaccines