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We describe a 8,724-nucleotide-long picornavirus genome encoding a single 2,470-aa polyprotein obtained from the feces of a wild mouse. Rosavirus is genetically closest to the double ORF Dicipivirus found in canine feces that is currently the only picornavirus with a second internal ribosome entry site (IRES). Of note, a section of rosavirus' 5'UTR showed strong sequence and structural conservation with the type II IRES from the Parechovirus and Hungarovirus genera possibly reflecting exchange of genetic modules between genera. Based on genetic distance criteria rosavirus qualifies as prototype of a new genus of the Picornaviridae family.

Original publication

DOI

10.1007/s11262-013-0968-1

Type

Journal article

Journal

Virus Genes

Publication Date

12/2013

Volume

47

Pages

556 - 558

Keywords

5' Untranslated Regions, Animals, Base Sequence, Dogs, Feces, Mice, Molecular Sequence Data, Phylogeny, Picornaviridae, Picornaviridae Infections, Rodent Diseases