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We report the first identification, genetic characterization and disease association studies of several novel species of canine bocaviruses (CBoV). Evolutionary analysis confirmed that CBoV are genetically distinct from the only other known canine bocavirus, minute virus of canines, with which they share less than 63, 62 and 64 % protein identity in NS, NP and VP genes, respectively. Comparative genetic analysis of 37 VP gene variants found in diseased and healthy animals showed that these novel viruses are genetically highly diverse and are common in canine respiratory infections that have remained undetected until now. Interestingly, we observed that a CBoV genotype with a unique deletion in the VP2 gene was significantly more prevalent in animals with respiratory diseases compared with healthy animals.

Original publication

DOI

10.1099/vir.0.036624-0

Type

Journal article

Journal

J Gen Virol

Publication Date

02/2012

Volume

93

Pages

341 - 346

Keywords

Animals, Bocavirus, Cluster Analysis, DNA, Viral, Dog Diseases, Dogs, Models, Molecular, Molecular Conformation, Molecular Sequence Data, Parvoviridae Infections, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Viral Proteins