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The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.

Original publication

DOI

10.1128/AAC.00840-16

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

08/2016

Volume

60

Pages

5068 - 5071

Keywords

Acinetobacter, Anti-Bacterial Agents, Carbapenems, Drug Resistance, Multiple, Bacterial, Escherichia coli, Integrons, Microbial Sensitivity Tests, Plasmids, Pseudomonas aeruginosa, beta-Lactamases