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The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as ∼0.3%. The method exhibits O(NlogN) scaling with sample size N, enabling fast and accurate phasing of even larger cohorts.

Original publication




Journal article


Nat Genet




817 - 820


Algorithms, Biological Specimen Banks, Cohort Studies, Computational Biology, Datasets as Topic, European Continental Ancestry Group, Genetics, Population, Genome, Human, Genomics, Haplotypes, High-Throughput Nucleotide Sequencing, Humans, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, United Kingdom