Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia
Picaud S., Leonards K., Lambert J-P., Dovey O., Wells C., Fedorov O., Monteiro O., Fujisawa T., Wang C-Y., Lingard H., Tallant C., Nikbin N., Guetzoyan L., Ingham R., Ley SV., Brennan P., Muller S., Samsonova A., Gingras A-C., Schwaller J., Vassiliou G., Knapp S., Filippakopoulos P.
BET bromodomains are unique targeting modules that mediate primary transcription response.