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Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.

Original publication

DOI

10.1038/cr.2016.113

Type

Journal article

Journal

Cell Res

Publication Date

11/2016

Volume

26

Pages

1176 - 1177