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© 2016 Elsevier Inc. All rights reserved. There are still a significant number of bacterial infections for which no vaccines are available and several of the existing vaccines are suboptimal. However, the science of genomics is providing new approaches, including reverse vaccinology, identifying new candidate antigens, and assessing potential vaccine coverage. These advances are stimulating a reappraisal of the field and new candidate vaccines are emerging.

Original publication





Book title

The Vaccine Book: Second Edition

Publication Date



311 - 329