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Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.

Original publication

DOI

10.1016/S0140-6736(03)14847-7

Type

Journal article

Journal

Lancet

Publication Date

22/11/2003

Volume

362

Pages

1723 - 1724

Keywords

Diabetes Mellitus, Type 1, Humans, Intercellular Adhesion Molecule-1, Pedigree, Polymorphism, Single Nucleotide