Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Dendrou CA., Cortes A., Shipman L., Evans HG., Attfield KE., Jostins L., Barber T., Kaur G., Kuttikkatte SB., Leach OA., Desel C., Faergeman SL., Cheeseman J., Neville MJ., Sawcer S., Compston A., Johnson AR., Everett C., Bell JI., Karpe F., Ultsch M., Eigenbrot C., McVean G., Fugger L.
Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases.