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OBJECTIVE: To examine trends in prescription of cough medicines over the period 2002-2015 in children aged 1 month to 12 years admitted to Kenyan hospitals with cough, difficulty breathing or diagnosed with a respiratory tract infection. METHODS: We reviewed hospitalisation records of children included in four studies providing cross-sectional prevalence estimates from government hospitals for six time periods between 2002 and 2015. Children with an atopic illness were excluded. Amongst eligible children, we determined the proportion prescribed any adjuvant medication for cough. Active ingredients in these medicines were often multiple and were classified into five categories: antihistamines, antitussives, mucolytics/expectorants, decongestants and bronchodilators. From late 2006, guidelines discouraging cough medicine use have been widely disseminated and in 2009 national directives to decrease cough medicine use were issued. RESULTS: Across the studies, 17 963 children were eligible. Their median age and length of hospital stay were comparable. The proportion of children who received cough medicines shrank across the surveys: approximately 6% [95% CI: 5.4, 6.6] of children had a prescription in 2015 vs. 40% [95% CI: 35.5, 45.6] in 2002. The most common active ingredients were antihistamines and bronchodilators. The relative proportion that included antihistamines has increased over time. CONCLUSIONS: There has been an overall decline in the use of cough medicines among hospitalised children over time. This decline has been associated with educational, policy and mass media interventions.

Original publication

DOI

10.1111/tmi.12831

Type

Journal article

Journal

Trop Med Int Health

Publication Date

03/2017

Volume

22

Pages

363 - 369

Keywords

Kenya, cough medicines, hospitalised children, prescription practices, respiratory tract infection, Antitussive Agents, Bronchodilator Agents, Child, Preschool, Cough, Cross-Sectional Studies, Drug Prescriptions, Dyspnea, Expectorants, Histamine Antagonists, Hospitalization, Humans, Inappropriate Prescribing, Infant, Kenya, Nasal Decongestants, Practice Patterns, Physicians', Respiratory System Agents, Respiratory Tract Infections