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To evaluate the risk of transmission of SARS coronavirus outside of the health-care setting, close household and community contacts of laboratory-confirmed SARS cases were identified and followed up for clinical and laboratory evidence of SARS infection. Individual- and household-level risk factors for transmission were investigated. Nine persons with serological evidence of SARS infection were identified amongst 212 close contacts of 45 laboratory-confirmed SARS cases (secondary attack rate 4.2%, 95% CI 1.5-7). In this cohort, the average number of secondary infections caused by a single infectious case was 0.2. Two community contacts with laboratory evidence of SARS coronavirus infection had mild or sub-clinical infection, representing 3% (2/65) of Vietnamese SARS cases. There was no evidence of transmission of infection before symptom onset. Physically caring for a symptomatic laboratory-confirmed SARS case was the only independent risk factor for SARS transmission (OR 5.78, 95% CI 1.23-24.24).

Original publication

DOI

10.1017/S0950268806006996

Type

Journal article

Journal

Epidemiol Infect

Publication Date

04/2007

Volume

135

Pages

392 - 401

Keywords

Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Disease Outbreaks, Female, Humans, Infant, Male, Middle Aged, Risk Factors, Severe Acute Respiratory Syndrome, Vietnam