Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.

Original publication




Journal article


J Exp Med

Publication Date





368 - 380


Cells, Cultured, Epitopes, Female, HLA Antigens, Histocompatibility Antigens, Homozygote, Humans, Immunologic Techniques, Immunosuppression, In Vitro Techniques, Lymphocyte Culture Test, Mixed, Male, T-Lymphocytes, Time Factors