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The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

Original publication

DOI

10.1016/j.cub.2004.03.026

Type

Journal article

Journal

Curr Biol

Publication Date

06/04/2004

Volume

14

Pages

R284 - R286

Keywords

CCCTC-Binding Factor, Chromatin, DNA Methylation, DNA-Binding Proteins, Female, Genomic Imprinting, Humans, Male, Protein Binding, RNA, Long Noncoding, RNA, Untranslated, Repressor Proteins