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In a recent article, a candidate pathway approach was taken to try to identify single nucleotide polymorphisms (SNP) that make up the genetic variation, which underlies the phenotypic variation seen between individuals in their susceptibility to cancer and the progression of their disease. The p53 stress response pathway was chosen given its well-documented importance in tumor suppression. A SNP was found which associates with the attenuation of the p53 pathway and the acceleration of tumor formation in humans and data was presented which describe a molecular mechanism for these phenotypes.

Original publication

DOI

10.1158/0008-5472.CAN-05-0825

Type

Journal article

Journal

Cancer Res

Publication Date

01/07/2005

Volume

65

Pages

5481 - 5484

Keywords

Animals, Genetic Predisposition to Disease, Humans, Neoplasms, Nuclear Proteins, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-mdm2