Spatio-temporal epidemiology of Campylobacter jejuni enteritis, in an area of Northwest England, 2000–2002
GABRIEL E., WILSON DJ., LEATHERBARROW AJH., CHEESBROUGH J., GEE S., BOLTON E., FOX A., FEARNHEAD P., HART CA., DIGGLE PJ.
SUMMARYA total of 969 isolates of Campylobacter jejuni originating in the Preston, Lancashire postcode district over a 3-year period were characterized using multi-locus sequence typing. Recently developed statistical methods and a genetic model were used to investigate temporal, spatial, spatio-temporal and genetic variation in human C. jejuni infections. The analysis of the data showed statistically significant seasonal variation, spatial clustering, small-scale spatio-temporal clustering and spatio-temporal interaction in the overall pattern of incidence, and spatial segregation in cases classified according to their most likely species-of-origin.