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© 2017, Springer International Publishing AG. We model the evolution of bone mineral density measurements in a cohort of HIV-infected persons by DXA scans. We define the minimum T-score (MTS) from the DXA measures at four different sites and propose a disease progression model for the transitions between three different health states: normal, osteopenia, and osteoporosis. A linear mixed model for the MTS is fitted, the estimated ages at osteopenia and osteoporosis onset are imputed, and the transition probabilities between the states are estimated.

Original publication





Book title

Trends in Mathematics

Publication Date





41 - 45