Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation
Kassaar O., McMahon SA., Thompson R., Botting CH., Naismith JH., Stewart AJ.
Key PointsThe x-ray crystal structure of the N2 domain from HRG at 1.93 Å resolution is presented. The structure reveals an S-glutathionyl adduct at Cys185, which has implications for angiogenic regulation.