The Effects of Almitrine on the Ventilatory Response to Hypoxia and Hypercapnia in Normal Subjects
Stradling JR., Barnes P., Pride NB.
<jats:p>1. Almitrine at a dose of 0·5 mg h−1 kg−1 given intravenously over 2 h had no effect on resting ventilation in normal males.</jats:p> <jats:p>2. There was a small, but insignificant, rise in the hypercapnic drive to breathe as compared with placebo.</jats:p> <jats:p>3. A large rise in the hypoxic drive to breathe was seen in response to almitrine.</jats:p> <jats:p>4. These findings support the claim that almitrine has its action on ventilation via the peripheral chemoreceptors.</jats:p> <jats:p>5. No correlation between blood levels of almitrine and the rise in hypoxic response was seen.</jats:p>