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<jats:p>1. After a run-in period, six healthy, recumbent, water-loaded male subjects breathed through an inspiratory threshold load for 90 min. To correct for prolonged recumbency, a similar protocol was followed on a separate control day, but without an inspiratory load.</jats:p> <jats:p>2. A negative intrathoracic pressure of at least 30 cmH2O was required to overcome the threshold load.</jats:p> <jats:p>3. Urine was collected every 30 min and analysed for sodium concentration.</jats:p> <jats:p>4. Plasma samples were collected every 30 min and analysed for atrial natriuretic peptide concentration.</jats:p> <jats:p>5. The inspiratory load had no effect on urine volume, urinary sodium excretion or plasma atrial natriuretic peptide levels.</jats:p>

Original publication

DOI

10.1042/cs0780311

Type

Journal article

Journal

Clinical Science

Publisher

Portland Press Ltd.

Publication Date

01/03/1990

Volume

78

Pages

311 - 313