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<jats:p>1. Almitrine at a low dose of 100 mg orally significantly raises Pao2 and lowers Paco2 in patients with chronic obstructive pulmonary disease, compared with placebo, when they were breathing air or 28% oxygen.</jats:p> <jats:p>2. The estimated ideal alveolar — arterial Po2 difference was less after almitrine compared with placebo, when patients were breathing either air or 28% oxygen.</jats:p> <jats:p>3. After almitrine overall ventilation breathing air increased by 10% but this did not reach statistical significance. During 28% oxygen breathing almitrine hardly altered overall ventilation but the inspiratory duty cycle (Ti/Ttot.) decreased and mean inspiratory flow rate (VT/Ti) increased compared with placebo. These changes were significant on a paired t-test (P&lt;0.05).</jats:p> <jats:p>4. Changes in both volume and pattern of breathing may explain the improved gas exchange in the lung after almitrine.</jats:p>

Original publication

DOI

10.1042/cs0660435

Type

Journal article

Journal

Clinical Science

Publisher

Portland Press Ltd.

Publication Date

01/04/1984

Volume

66

Pages

435 - 442