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OBJECTIVE: To determine whether non-epidemiologically related, antibiotic-resistant isolates of Acinetobacter baumannii from different geographical origins possess common type 1 integrons. METHODS: The epidemiologic relationships between seven A. baumannii strains recovered from different Spanish hospitals were established by pulsed-field gel electrophoresis, the presence of integrons being determined by PCR and DNA sequencing. RESULTS: Integron analysis showed the presence of four different integrons, containing six different known genes (aacC1, aacA4, aadA1, aadB, oxa21 and oxa37) plus an ORF. It was found that the same integron was present in different unrelated strains and that related strains could have different integrons. CONCLUSION: These results show the potential risk of integron dissemination among different strains of A. baumannii.

Type

Journal article

Journal

Clin Microbiol Infect

Publication Date

09/2003

Volume

9

Pages

907 - 911

Keywords

Acinetobacter Infections, Acinetobacter baumannii, DNA, Bacterial, Drug Resistance, Multiple, Bacterial, Electrophoresis, Gel, Pulsed-Field, Humans, Integrons, Microbial Sensitivity Tests, Phylogeny, Polymerase Chain Reaction, Sequence Analysis, DNA, Spain