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We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+).

Original publication

DOI

10.1038/sj.bjc.6604737

Type

Journal article

Journal

Br J Cancer

Publication Date

18/11/2008

Volume

99

Pages

1726 - 1728

Keywords

Adenoma, Colorectal Neoplasms, Hereditary Nonpolyposis, Frameshift Mutation, Humans, Microsatellite Instability, Myosin Heavy Chains, Smooth Muscle Myosins