Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region. Previous LOH and CGH studies have refined this region to 7q22.3-q31, although the target gene has not been identified. Here, we have used tiling-path resolution microarray CGH to further refine the region and to identify homozygous deletions in fibroids. Furthermore, we have screened all manually annotated genes in the region for mutations. We have refined the minimum deleted region at 7q22.3-q31 to 2.79 Mbp and identified a second region of deletion at 7q34. However, we identified no pathogenic coding variation.

Original publication

DOI

10.1002/gcc.20427

Type

Journal article

Journal

Genes Chromosomes Cancer

Publication Date

05/2007

Volume

46

Pages

451 - 458

Keywords

Chromosome Mapping, Chromosomes, Human, Pair 7, DNA Damage, DNA Mutational Analysis, DNA, Neoplasm, Female, Humans, Hysterectomy, Leiomyoma, Neoplasm Proteins, Nucleic Acid Hybridization, Oligonucleotide Array Sequence Analysis, Sequence Deletion, Uterine Neoplasms