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We describe the cloning of a multifunctional folic acid synthesis (fas) gene from Pneumocystis carinii. The nucleotide sequence contains an open reading frame interrupted by three introns, that encodes a protein of 740 amino acids with an Mr of 97,278. The predicted Fas protein has homology to two enzyme domains, dihydropteroate synthase and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, both of which are involved in folate synthesis, and at least one other region of unknown function.


Journal article



Publication Date





213 - 218


Amino Acid Sequence, Base Sequence, Cloning, Molecular, Dihydropteroate Synthase, Diphosphotransferases, Folic Acid, Genes, Fungal, Molecular Sequence Data, Phosphotransferases, Pneumocystis