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The three-dimensional structure of human muscle aldolase has been solved at 5 A resolution with the use of two isomorphous heavy atom derivatives. The enzyme's four subunits are arranged about three mutually perpendicular intersecting twofold axes to form a compact spherical molecule. The subunit boundaries are clearly defined but a possible domain structure is not apparent in this preliminary electron density map.

Original publication




Journal article


Philos Trans R Soc Lond B Biol Sci

Publication Date





209 - 214


Binding Sites, Chemical Phenomena, Chemistry, Crystallization, Fructose-Bisphosphate Aldolase, Humans, Macromolecular Substances, Models, Molecular, Muscles, Protein Conformation, X-Ray Diffraction