Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Monoclonal antibodies to human immunodeficiency virus (HIV)-2 reverse transcriptase have been raised with the ultimate goal of generating Fab fragments for future co-crystallization studies. A number of mouse monoclonal antibodies to recombinant HIV-2 reverse transcriptase have been obtained and characterized in terms of the possible epitopes they recognise together with cross-reactivity with a related reverse transcriptase. The antibodies were shown to fall into three groups that recognize different regions of the reverse transcriptase enzyme. One antibody, which recognizes part of the RNase H domain, demonstrated cross-reactivity between the HIV-1 and HIV-2 reverse transcriptase.


Journal article


J Acquir Immune Defic Syndr

Publication Date





1187 - 1193


Amino Acid Sequence, Animals, Antibodies, Monoclonal, Blotting, Western, Cross Reactions, Epitopes, HIV Reverse Transcriptase, HIV-1, HIV-2, Humans, Hybridomas, Mice, Molecular Sequence Data, Mutagenesis, Site-Directed, RNA-Directed DNA Polymerase