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Monoclonal antibodies to human immunodeficiency virus (HIV)-2 reverse transcriptase have been raised with the ultimate goal of generating Fab fragments for future co-crystallization studies. A number of mouse monoclonal antibodies to recombinant HIV-2 reverse transcriptase have been obtained and characterized in terms of the possible epitopes they recognise together with cross-reactivity with a related reverse transcriptase. The antibodies were shown to fall into three groups that recognize different regions of the reverse transcriptase enzyme. One antibody, which recognizes part of the RNase H domain, demonstrated cross-reactivity between the HIV-1 and HIV-2 reverse transcriptase.

Type

Journal article

Journal

J Acquir Immune Defic Syndr

Publication Date

11/1993

Volume

6

Pages

1187 - 1193

Keywords

Amino Acid Sequence, Animals, Antibodies, Monoclonal, Blotting, Western, Cross Reactions, Epitopes, HIV Reverse Transcriptase, HIV-1, HIV-2, Humans, Hybridomas, Mice, Molecular Sequence Data, Mutagenesis, Site-Directed, RNA-Directed DNA Polymerase