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Membrane protein structural biology is still a largely unconquered area, given that approximately 25% of all proteins are membrane proteins and yet less than 150 unique structures are available. Membrane proteins have proven to be difficult to study owing to their partially hydrophobic surfaces, flexibility and lack of stability. The field is now taking advantage of the high-throughput revolution in structural biology and methods are emerging for effective expression, solubilisation, purification and crystallisation of membrane proteins. These technical advances will lead to a rapid increase in the rate at which membrane protein structures are solved in the near future.

Original publication

DOI

10.1016/j.sbi.2008.07.001

Type

Journal article

Journal

Curr Opin Struct Biol

Publication Date

10/2008

Volume

18

Pages

581 - 586

Keywords

Chromatography, Gel, Crystallography, X-Ray, Humans, Magnetic Resonance Spectroscopy, Membrane Proteins, Models, Molecular, Molecular Conformation, Protein Conformation, Receptors, G-Protein-Coupled