CLEC-2 is required for development and maintenance of lymph nodes
Bénézech C., Nayar S., Finney BA., Withers DR., Lowe K., Desanti GE., Marriott CL., Watson SP., Caamaño JH., Buckley CD., Barone F.
Key Points CLEC-2 is necessary for lymphatic cell proliferation and lymph node anlage persistence after birth. Lack of CLEC-2 expression on megakaryocytes and platelets compromises lymph node integrity in adult life.