Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Experiments with mouse systems have shown that antigens recognized on tumors by cytolytic T lymphocytes can be the targets of immune responses that destroy the tumor cells without exerting harmful effects on normal tissues. In recent years, a number of genes that code for these antigens have been identified. The first gene studied, MAGE-1, coded for an antigen recognized by an autologous cytolytic T-cell clone. It belongs to a family comprising at least twelve members, but the function of the proteins encoded remains unknown. These genes have no expression in normal tissues (but testis and placenta); the tumoral peptides are presented to the immune system by specific HLA molecules. Some other tumoral antigens are not restricted to tumors but appear on normal melanocytes (tyrosinase, gp100...). Knowing these genes opens new possibilities in specific cancer immunotherapy.

Type

Journal article

Journal

Medecine/Sciences

Publication Date

01/01/1995

Volume

11

Pages

1279 - 1287