Nbeal2 interacts with Dock7, Sec16a, and Vac14
Mayer L., Jasztal M., Pardo M., Aguera de Haro S., Collins J., Bariana TK., Smethurst PA., Grassi L., Petersen R., Nurden P., Favier R., Yu L., Meacham S., Astle WJ., Choudhary J., Yue WW., Ouwehand WH., Guerrero JA.
Key PointsNbeal2 interacts with Dock7, Sec16a, and Vac14; and missense variants that cause GPS disrupt the binding of Dock7 and Vac14. The level of the α-granule protein Dock7 in platelets from Nbeal2−/− mice and GPS cases is reduced and its signaling pathway is dysregulated.