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Recent studies have shed new light on the role of the fibrinolytic system in the pathogenesis of pleural organization, including the mechanisms by which the system regulates mesenchymal transition of mesothelial cells and how that process affects outcomes of pleural injury. The key contribution of plasminogen activator inhibitor-1 to the outcomes of pleural injury is now better understood as is its role in the regulation of intrapleural fibrinolytic therapy. In addition, the mechanisms by which fibrinolysins are processed after intrapleural administration have now been elucidated, informing new candidate diagnostics and therapeutics for pleural loculation and failed drainage. The emergence of new potential interventional targets offers the potential for the development of new and more effective therapeutic candidates.

Original publication

DOI

10.1152/ajplung.00501.2017

Type

Journal article

Journal

Am J Physiol Lung Cell Mol Physiol

Publication Date

01/05/2018

Volume

314

Pages

L757 - L768

Keywords

fibrinolysis, loculation, pleural disease