A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling
Gorvin CM., Babinsky VN., Malinauskas T., Nissen PH., Schou AJ., Hanyaloglu AC., Siebold C., Jones EY., Hannan FM., Thakker RV.
A disease-associated mutation disrupts a calcium-sensing receptor structural motif and causes biased signaling through β-arrestin.